Cagrilintide (N-terminal)

Cagrilintide(N-terminal) ,The N-terminal fragment of Cagrilintide is a peptide sequence derived from the N-terminal region of the full-length Cagrilintide, a long-acting amylin analogue for obesity and type 2 diabetes. This fragment contains key residues important for interaction with the amylin receptor complex (calcitonin receptor/CTR and RAMPs) and is often synthesized for research into receptor binding, structure-activity relationships, and analogue development. As a segment, it may retain partial receptor activity and is useful for elucidating binding mechanisms and for developing improved therapeutics.

Appearance

• White to off-white solid powder or lyophilized solid

Source

• Synthetically produced by solid-phase peptide synthesis (SPPS)

• Not typically isolated from natural sources

Molecular Weight and Structure

• Molecular weight: Depends on the specific fragment length and sequence; much lower than intact Cagrilintide (full-length: ~3917.9 Da)

• Structure: Corresponds to the amino acid sequence from the N-terminus with a free amino (N-term) and carboxyl (C-term) group

Biological Activity

• May bind the amylin receptor complex (CTR/RAMPs)

• Activity dependent on fragment sequence, length, and post-translational modifications

• Possible effects on gastric emptying, appetite regulation, and glucose metabolism, but likely less potent than full-length Cagrilintide

Purity and Microbial Contamination

Shelf Life and Storage

• Shelf life: 1–2 years from manufacture; refer to COA

• Store at -20°C or below, inert atmosphere (argon/nitrogen), tightly sealed, dry

• Protect from light and avoid repeated freeze-thaw cycles

• Lyophilized peptides are most stable

Applications

• Receptor binding studies (amylin receptor/CTR/RAMPs)

• Structure-activity relationship (SAR) studies for amylin analogues

• Reference for peptide synthesis and purification

• Pharmacological characterization of N-terminal effects

• Basis for the design of modified amylin analogues

Key Characteristics

• Sequence derived from N-terminus of Cagrilintide

• Interacts with amylin receptor complex

• Synthetic, high-purity, and potentially bioactive

• Useful for understanding Cagrilintide’s mechanism of action

Citation 

• Use keywords like “Cagrilintide amylin receptor N-terminal,” “amylin structure-activity relationship,” “amylin analogue N-terminal,” and “Cagrilintide synthesis” on Google Scholar and chemical databases

• Review patents for detailed sequence information

• Consult publications on amylin receptor structure, SAR, and clinical research for Cagrilintide and analogues

• Seek out articles on receptor agonism, peptide drug design, and amylin pharmacology for close analogues and fragments

• Once the exact sequence is known, refine literature searches for studies focusing on that peptide fragment specifically