Description:
Humanized monoclonal IgG antibodies are engineered immunoglobulin G molecules in which the non-human (typically murine) variable regions are modified to closely resemble human antibody sequences. This process reduces immunogenicity while preserving high antigen-binding affinity and specificity.
These antibodies are widely used in therapeutic applications, particularly in oncology, autoimmune diseases, and infectious diseases. Humanized IgG antibodies also serve as critical tools in diagnostic assays and biomarker detection, offering reliable performance with minimal cross-reactivity.
Key Features:
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Reduced immunogenicity compared to chimeric or murine antibodies
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High specificity and affinity for target antigens
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Available in IgG1, IgG2, IgG4 isotypes for functional flexibility
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Suitable for therapeutic development and in vitro assays
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Custom conjugation (e.g., biotin, fluorophores) available upon request
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