Description:
Recombinant adeno-associated virus (rAAV) vectors are powerful tools for gene delivery, offering high transduction efficiency, low immunogenicity, and long-term expression in both dividing and non-dividing cells. These vectors are derived from the wild-type AAV genome but are engineered to carry therapeutic or reporter genes in place of viral genes, making them replication-incompetent and safe for research and clinical use.
rAAV vectors are widely used in gene therapy, functional genomics, neuroscience, and preclinical disease modeling due to their ability to target specific tissues with minimal toxicity. Various serotypes are available to achieve cell-type or tissue-specific delivery.
Key Features:
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High-efficiency gene delivery to target tissues
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Broad tropism with multiple AAV serotypes (e.g., AAV2, AAV5, AAV8, AAV9)
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Long-term expression with episomal persistence
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Non-integrating, non-pathogenic vector
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Suitable for in vivo and in vitro applications
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